Morgan ECFP4 · Tanimoto coefficient

Measure real molecular similarity

Compare two molecules, or search our database (7K chemicals, 3,381 formulas) for everything that resembles your target. The same algorithm used by Schrödinger and BenevolentAI.

Molecule A — name or SMILES

Molecule B — name or SMILES

Results

Pick a mode and enter the inputs on the left.

How it works: Each molecule is converted to a Morgan ECFP4 fingerprint (radius = 2, 2048 bits) and the Tanimoto coefficient is computed as |A∩B| / |A∪B|. Tiers: 0.85–1.0 = essentially identical · 0.6–0.85 = close analog · 0.3–0.6 = related family · < 0.3 = different scaffolds. This is the same protocol used in drug discovery and materials science.